7 Best Flea Treatment for Puppies 2022 Reviewed

Flea Treatment is vital for your puppies’ healthy life. Flea may cause skin allergies, typhus, or even transmit parasites such as tapeworms. 

  • Your top daily care for puppies is essential. So, could you be looking for the best flea treatment for your puppies?

So, let’s get started! Related: Fleas Treatment for Dogs

In a Rush? View top Flea Treatment for Puppies 

1. Our #1 Pick: Natural-Care Flea Spray for Puppies (12+ weeks), Dogs

Natural Care Flea and Tick Spray for Dogs and Cats | Flea Treatment for Dogs and Cats | Flea Killer...
  • A WORKING SOLUTION - Natural Care Flea & Tick Home Spray works with you to kill fleas, flea eggs, and ticks on contact. And it repels mosquitoes. Just apply it wherever the pests are found, inside and...
  • NO HARSH CHEMICALS - The formula uses the natural power of plant extracts, like peppermint oil and clove extract, to get the job done.
  • NO STAINS - It’s safe to use on pet bedding, pillows, blankets, carpets, rugs, dras, upholstery, countertops, and so much more. And you don’t have to worry about it leaving a stain.
  • SAFE TO USE - You can use it on your dogs and cats, 12 weeks and older, as directed. Since it’s a plant-based formula, it’s safe to use around the whole family.
  • QUALITY - The bottle is packaged in such a way that it won’t leak when it’s shipped to you.

2. #2 Pick: Vet’s Best Topical Tick& Flea Spot-on Spray

Vet's Best Flea and Tick Spot-on Drops | Topical Flea Treatment Drops for Dogs | Flea killer with...
  • SAFE AND EFFECTIVE: Vet's Best Flea and Tick Spot-On Formula kills and repels fleas and ticks with natural ingredients.
  • NATURAL FORMULA: Spot-On uses key, natural ingredients (clove leaf oil, thyme white oil, and cinnamon oil) with absolutely no pyrethrins, permethrins, or cedar oil
  • EASY APPLICATION: Simply use the supplied dropper applicator and squeeze the specified amount betweeh the shoulder blades and base of the tail.
  • SAFE TO USE FOR DOGS: Formulated for dogs and puppies 12 weeks or older when used as directed.
  • MADE IN THE USA: Our products are proudly manufactured in the USA with quality domestic and internationally sourced ingredients.

Vet’s Best Natural is a natural home spray that will help treat your flea-infested puppy. 

The key thing is the presence of natural ingredients clove extract and peppermint oil used to kill and control flea helps you eliminate the use of pyrethrins, permethrins, or cedar oil-related sprays.

Vet’s Best Natural kills adult fleas, larvae, and eggs on contact. It can repel mosquitoes and other home flies.

The non-staining formula of Vet’s Best Natural doesn’t affect your carpet, furniture, floor, or harm your plants (safe).

Vet’s Best Natural contains a mixed formulation of peppermint oil and eugenol, which leaves a pleasant scent after use. It is not harmful to children. You can even use it to treat various places in your home.

Vet’s Best Natural is best when used for puppies aged 12 weeks or older. It can also be used to treat cats and kittens.

It is easier to use—the Vet’s Best Natural nozzle is designed to concentrate the spray without wastage on the trigger.


  • Environmentally friendly – no pollution.
  • Fast killing and Can treat cats and kittens.
  • Not harmful to kids and is easy to use.
  • Pleasant scent and Non-staining.
  • It can be used for home flea treatment.


  • Requires multiple applications.
  • Clove fragrance effects.

Related: Best Dog Brush for Short Hair Shedding

3. #3 Pick: Wondercide – Mosquito, Tick, & Flea Spray for Puppies

Wondercide - Flea, Tick and Mosquito Spray for Dogs, Cats, and Home - Flea and Tick Killer, Control,...
  • KILLS & REPELS. Using natural essential oils, this spray is proven to kill by contact, repel and prevent 98-100% of fleas, ticks and mosquitoes. It eliminates the entire pest life cycle, including...
  • TREAT NATURE WITH NATURE. A safe and effective alternative to collars, pills, chewables, and drops that's powered by nature. Holistic vet approved. Enjoy worry-free peace of mind knowing your pets and...
  • SAFE FOR DOGS, CATS OF ALL AGES. Gentle enough to use on puppies, kittens, and senior pets as often as needed, yet powerful enough to fully eliminate pests on the skin and fur. Safe to use around the...
  • 3-IN-1 PLANT-BASED SOLUTION. For dogs, cats, and home! A home remedy that kills fleas throughout the house on carpet, furniture, bedding, and flooring. Also a repellent in pet environments like dog...
  • POWERFULLY EFFECTIVE. Powered by nature and proven to work. Give your pet the best advantage in protection against fleas and ticks with our non-harsh formula. Cruelty free, biodegradable, and Made in...

4. Bayer K9 Advantix II Flea for Small Dogs

K9 Advantix II Flea and Tick Prevention for Small Dogs (4-10 Pounds), 6 Pack
  • SIX MONTH PROTECTION: 6 monthly applications of K9 Advantix II flea and tick prevention for small dogs weighing 4 to 10 pounds
  • FLEA, TICK AND MOSQUITO PROTECTION: K9 Advantix II flea and tick prevention for dogs works through contact, so fleas, ticks and mosquitoes do not have to bite your dog to die
  • EASY TO APPLY: K9 Advantix II flea and tick control for dogs is an easy to apply topical formula
  • STARTS WORKING WITHIN 12 HOURS: Starts working to kill fleas within 12 hours and keeps working for 30 days
  • EFFECTIVE YEAR-ROUND: Suitable for effective year-round flea and tick treatment for small dogs

K9 Advantix II tops my list. This product will get rid of fleas from your puppy in 12 hours after application, and the treatment effects continue for 30 days. 

  • K9 Advantix II is veterinary-recommended flea control for small dogs that lay between 4 to 10 pounds.
  • It can also kill ticks, lice, repel mosquitoes, and biting flies in your kennel – an advantage/benefit not found in other flea products.

K9 Advantix II is a quick-acting (it’s activated in 5 minutes) flea product that work on contact due to its parasitostatic action mechanism.

It contains Permethrin, Imidacloprid, and Pyriproxyfen, active ingredients that instantly kill all flea on application.

This product has been manufactured with waterproof formula for practical application – it won’t be washed down if you apply it to your puppy during the rainy season.

K9 Advantix II is convenient as you can use it all year round – apply dose after one or two months.

Moreover, it’s easier to use; place the puppy’s skin’s tip gently and squeeze to expel the solution.


  • Quick-acting – 12 hours of action time.
  • Kills other insects like mosquitoes and lice.
  • Kills all stages of the flea.
  • Veterinarian recommended


  • Used in dogs only
  • More costly

5. PETARMOR Plus for Small Dogs

PetArmor Plus Flea and Tick Prevention for Dogs, Dog Flea and Tick Treatment, Waterproof Topical,...
  • EFFECTIVE, WATERPROOF FLEA TREATMENT FOR DOGS: PetArmor Plus is a waterproof, flea & tick topical prevention for dogs that kills fleas, flea eggs, flea larvae, ticks, and chewing lice for up to 30...
  • TRUSTED, VET QUALITY FORMULA: Containing fipronil and (S)-methoprene, the same active ingredients as FRONTLINE Plus for Dogs. PetArmor Plus for Dogs has a powerful formula that starts to kill fleas...
  • BREAK THE FLEA CYCLE: Unlike other flea and tick treatments that may temporarily suppress flea activity, PETARMOR Plus Dog Flea Treatment works by effectively breaking the flea life cycle. Kill flea...
  • FLEA AND TICK PROTECTION: PetArmor Plus for Dogs flea drops protects your furry family members from brown dog ticks, American dog ticks, Lone Star ticks, and deer ticks (which may transmit Lyme...
  • EASY-TO-USE, LONG-LASTING: PetArmor Plus flea and tick treatment comes with six (6) waterproof topical applications that provide your pet flea protection and control for six (6) months.

PetArmor Plus cares for your small puppies, especially in flea control. It conveniently provides top-quality protection without visiting the vet. 

  • Flea treatment dose contains fipronil that begins to kill fleas, larva,e, and eggs within 5 minutes and kills all flea in 24 hours.
  • It also kills ticks and chewing lice. A single PetArmor Plus application can be effective for 30 days.

PetArmor Plus is a quick-acting tropical flea killer. It breaks the flea life cycle and inhibits/prevents the infestation up to 12 weeks for a single dose.

This product can control mites, which cause sarcoptic mange disease, and deer ticks, which cause Lyme disease.

PetArmor Plus is waterproof. The greasy solution sticks on your puppy’s skin, thus initiating quick action.

The application of PetArmor Plus requires you to squeeze and smear the product on various puppy’s ski pointsn.

Keep off any treated puppy away from friends. In case the grease doesn’t deplete in 48 hours, use a wet washcloth to remove any remains.

PetArmor Plus doesn’t irritate your puppy during and after application unless it is allergic.



  • Can only be used on the dog.
  • Slightly costly.

Related: Vacuum for Dog Hair

6. Frontline Plus for Dogs Small Dog (5-22 pounds)

FRONTLINE Plus Flea and Tick Treatment for Dogs (Medium Dog, 23-44 Pounds, 6 Doses)
  • Waterproof flea and tick treatment for dogs: Frontline Plus for Dogs provides waterproof, fast-acting, long-lasting flea and tick treatment and control for your dog. This product is approved for use...
  • Break the flea life cycle with frontline: Frontline flea and tick treatment for dogs kills adult fleas plus flea eggs and larvae to stop existing infestations and prevent establishment of new...
  • Kills fleas and ticks: Frontline flea and tick treatment for dogs kills fleas, flea eggs, lice, and ticks. This flea and tick treatment kills ticks, including those that may transmit Lyme disease
  • Trusted flea and tick protection for dogs: Frontline has been trusted by veterinarians for nearly 20 years. Made with 2 tough killing ingredients, fipronil and (S)-methoprene – one to kill adult...
  • Lasting flea and tick protection: Frontline's long-lasting formula is stored in the oil glands of the pet’s skin to give non-stop flea and tick protection for a full 30 days. Frontline flea and tick...

Frontline Plus is a trusted flea protection product for your puppy. With veterinary approval for nearly 20 years, Frontline Plus can kill flea and their eggs 12 hours after application. 

This product is suitable for puppies aged 8 weeks or older. It’s more suited/effective for puppies weighing within the range of 2 to 22 pounds.

  • It provides waterproof protection and a treatment action for 30 days from the time of application.
  • The serum Frontline Plus has stick properties that limit it from being washed down.

Frontline Plus is manufactured with quick-acting (it’s activated in 2 to 3 minutes after application) fipronil and S-methoprene killing ingredients that ensure that all flea stages are eradicated.

It does not affect your puppy’s skill. In fact, it offers extra protection by killing ticks, lice, and other pests that cause Lyme disease.

Frontline Plus also prevents/inhibits infestation and the establishment of new fleas on your dog.

It is long-lasting. A 6-dose package of Frontline Plus will give you 6 months of service time with six application rounds.


  • Top-quality – veterinary recommended.
  • Kills in 12 hours and 2 active ingredients.
  • Easy to apply and waterproof.
  • Long-lasting – 30 days per dose.
  • It can kill both Flea and eggs.


  • Doesn’t repel flea.
  • It is challenging to apply the serum.
  • The puppy may develop an allergy.

7. Capstar Fast-Acting Oral Flea Treatment for Dogs

Capstar Fast-Acting Oral Flea Treatment for Dogs
  • One oral tablet starts killing fleas within 30 minutes of administration
  • Tackle flea infestations fast – give Capstar and watch dead fleas fall off your pet
  • The convenience of an oral tablet available without a prescription from your vet
  • If your pet gets re-infested with fleas, you can safely give another dose as often as once per day
  • Includes 6 doses for use with cats and dogs weighing 2-25 (11.4 mg) pounds or dogs 25.1 – 125 (57 mg) pounds

Could you have been looking for a tablet treatment option for your puppy? Capstar is a fast-acting treatment tablet for your pappy.

It can be administered to a puppy weighing 4 pounds or more whose age is 4 weeks and above. 

  • A single tablet dose of Capstar will kill 90% of the adult fleas in 4 to 6 hours on your puppy. The product comes in two dosages.
  • For Puppy between 2 to 24 pounds, it will need to be given 11.4 mg and those between 25 to 124 to be treated using 57 mg tablets.

Capstar is convenient. A single tablet (give one pill a day) treats adult flea in 30 hours before laying eggs and manifesting.

This product can also be used to treat fleas from kittens and cats. It can eradicate pests that cause flea allergy dermatitis on your pets.

The dose is more comfortable and safe to administer as you will only require to place the oral tablet right into the puppy’s mouth or fix it in the food.

Capstar is pocket-friendly. A single packet has 6 tablets, which assures you of multiple dosages.


  • Safe to administer and Kills adult flea.
  • Less costly and Fast-acting – 4 to 6 hours.
  • It can also treat kittens and cats.
  • Can work for both puppy and mother – come in two doses.


  • Do not kill fleas’ eggs and larvae.

8. Seresto flea collar for dogs

Seresto Flea and Tick Collar for Dogs, 8-Month Flea and Tick Collar for Large Dogs (Over 18 Pounds),...
  • 8-MONTHS OF CONTINUOUS PROTECTION: Provides 8-months of continuous flea and tick prevention
  • WORKS THROUGH CONTACT: Seresto flea and tick collar for large dogs works through contact, so fleas and ticks do not have to bite your dog to die
  • VET-RECOMMENDED: Veterinarian-recommended flea and tick prevention for dogs in a convenient, odorless and non-greasy collar; No need for messy monthly treatments
  • STARTS WORKING WITHIN 24 HOURS: Starts to repel and kill fleas within 24 hours of initial application
  • FLEA AND TICK COLLAR: Flea and tick collar for large dogs also helps treat and control sarcoptic mange and kills lice

Have you been looking for a collar type of flea treatment for your puppy? Seresto flea collar is the best product to buy.

It provides continuous flea treatment and prevention for 6 to 8 months. 

Seresto flea collar works through contact whereby the active ingredients, i.e., flumethrin and imidacloprid, are released continuously in low concentration from the neck to all parts of your puppy. It can also repel and kill ticks/lice.

Seresto flea collar is best suitable for puppies weighing up to 18 pounds. The collar is made with a long-lasting material that doesn’t affect the comfort of your puppy.

  • You can easily tie and untie the Seresto flea collar due to its simple adjustable locking mechanism.
  • The Seresto flea collar is light in weight and thus won’t burden your puppy’s neck.

The non-greasy, odorless Seresto flea collar never messes your puppy’s skin. This collar is veterinary recommend for flea and tick protection.

Moreover, the collar is water-resistant/proof and will remain effective after swimming or rain/ exposure – your puppy should be washed once per month.

Seresto flea collar assures you all year protection without damaging your puppy. You can use a single Seresto flea collar for up to 6 months.


  • Light in weight and Last for 6 months.
  • Kill and repel flea and Non-grease.
  • Water-resistant and Easy to use.
  • No irritation.


  • Neck reaction (some puppies).
  • Costly than other collars.

9. Advantus Soft Chew

Advantus (Imidacloprid) 7-Count Flea Chews for Small Dogs 4-22 Pounds, Chewable Flea Treatment
  • Contains 7 small dog flea soft chews: A single dose of Advantus kills adult fleas on a dog. It is safe to repeat treatments as needed, up to once per day
  • Chewable flea treatment for dogs and puppies age 10 weeks and older
  • Advantus flea chews for small dogs start killing fleas within 1 hour
  • Advantus flea chews for small dogs are a convenient, savory soft chew
  • Available without a prescription

Could you be searching for a puppy flea treatment that is chewable? Advantus Soft Chew is a fast-killing product that would start flea killing in 60 minutes after feeding. 

Advantus Soft Chew is suitable for puppies aged 10 weeks or more. It should also weigh 4 pounds or greater.

The product comes in a soft chewable form that is convenient for your puppy. Its presumable smell and taste attract your puppy to feed just like other regular food.

  • Advantus Soft Chew is ideal for puppies suffering from protein food allergies.
  • The imidacloprid found in Advantus Soft Chew helps in the quick killing of adult fleas before laying eggs and infest.

A single dose of Advantus Soft Chew can eradicate up to 96% of the adult flea just in an hour.

It is safe to administer a single dose per day. In case your puppy shows dislike to Advantus Soft Chew, you can mix it with other puppy meals before feeding.

NB: Keep this product away from children. 


  • Quick-acting – in 1 hour.
  • Less costly.
  • Suitable for proteins allergic puppies.


  • Dangerous to children.
  • Can treat dogs/puppies only.
  • Short leaved effect.

How to Flea Treatment Puppies With Sensitive Skin

Puppies having sensitive skin need special treatment. Your puppy has sensitive skin if it has signed such as:

  1. Itching, dry and flaky skin, Hot spots on the skin.
  2. Red irritation, Stomach irritation.

These effects may be caused by:

  1. Harsh grooming, Fungal infections.
  2. Allergic foods, Gut health, or irritations.

You, therefore, need to need to observe proper treatment actions when handling such puppies. The following are possible ways in which you can use when treating your skin-sensitive puppy:

1. Use antifungal shampoo while cleaning your puppy’s skin. Press gently while cleaning spray clean to avoid peeling of the skin during scratching.

2. For gut health conditions, try improving your puppy’s appetite by use of probiotic supplements.

3. Use spray option of flea treatment products instead of serum or gel. This will help avoid direct contact with sensitive skin.

4. Treat kennel with flea killers such as K9 Advantix II to eliminate all flea that may cause allergy-like dermatitis and irritations.

5. Food allergic puppies, try to use a non-processed diet that is rice, fish, and basic vegetables based.

6. Those puppies sensitive to harsh grooming should be handled with a hypoallergenic shampoo with a pH-balanced label for puppies. The cleaning product should be free from parabens, ethoxylated, or sulfates.

7. Avoid taking your puppy to clouded public places. Ensure you dress your puppy in a short-fitting coat since most allergens hide in such attire.

Alternative Flea Treatments For Puppies?

Apart from the flea treatment option enlisted above, there are other alternatives that you can use to kill flea on your puppy. These include:

1. Diatomaceous Earth

Diatomaceous earth is a fine powder of microscopic remains of fossilized algae, which is non-toxic to humans.

Sprinkle the powder over the puppy’s and leave it for two days in an enclosed place. It will kill all the fleas by causing dehydration.

NB: Though non-toxic, Diatomaceous earth can be irritating when inhaled or touch your eye. Always use facemask during application.

2. Using flea-repelling plants.

There is a specific plant that scent that repels flea within your compound. These include Spearmint, Chrysanthemums, Thyme, Sage, Clove, Basil, Penny Royal, and Lavender.

Having some of these plants in your home or/near your kennel would be a permanent natural way of flea prevention.

3. Dish soap.

This is a great solution for adult fleas. Mix dish soap with warm water from a think stick fluid and place it in flea-infested rooms/kennel.

The solution will act as a trap since adult fleas will crawl in and get stuck in. You need to do this every 2 to 3 days.

4. Using Rosemary Product.

Rosemary is a great organic product that treats a few flea infestations on your puppy.

You can make the powder at home by grinding the rosemary herb mixed with fennel, rue, peppermint, or wormwood in a mortar/pestle.

Rub the powder on your puppy. Rosemary powder will mostly repel the flea that kills.


Treatment and prevention of flea infestation on your puppy require the proper selection of flea treatment products.

  • Always be keen to follow keenly instructions given on the labels.

Consult a veterinary or flea professionals if you are unable to carry out the Puppy’s flea treatment. Handle skin-sensitive puppies with great care.

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