7 Best Weed Killers for Flower Beds 2022

If you’re wondering how to get rid of the weeds in your flower bed or lawns, you’re not alone! You can get about it the ordinary way by hand plucking the weeds, but this is laborious and not a permanent solution.

The weeds will grow right back if not removed by the root. We believe that the best way to deal with it is by applying a weed killer or a herbicide.

Pre-emergent weed killers can be applied before planting the flower seeds, but there are post-emergent killers too if you spotted the weeds late. 

1. Our #1 Pick – Preen 2464238 Weed Killer & Preventer

How To Get Rid Of Dollar Weed

Preen 2464238 Extended Control Weed Preventer, 21.45 lb. -Covers 3,500 sq. ft
  • 1 Application blocks weeds up to 6 months
  • When used as directed Preen Extended Control Weed Preventer can be used around more than 600 perennials, groundcovers, shrubs and trees as listed on the product label
  • Can be sold as a refill for flip-top applicator bottle
  • Not intended for use on flower seeds, lawns, vegetable gardens, water gardens or other food-producing or edible plants
  • Not available for sale in NY

2. #2 Pick: Spectracide Grass and Weed Killer

Ortho GroundClear Weed & Grass Killer Ready-to-Use - Grass Weed Killer Spray, Use in Landscape Beds,...
  • Acts on contact—see results in 15 minutes
  • Ortho GroundClear Weed & Grass Killer works on all types of weeds and grasses
  • OMRI listed for organic gardening
  • Rainproof in 2 hours (upon drying)
  • Use on hardscapes, landscape beds, and around vegetable gardens (apply directly to weeds)

Ortho Ground Clear is a selective weed killer and works on post-emergent weeds in your flower beds. So your plants and flowers will not be affected by using this product. 

The Ortho Killer works on stubborn weeds like Bermuda grass, Oxalis, Chickweed, Clover, St. Augustine, Bluegrass, Centipede grass, among others.

Its advanced formula offered works fast in most environments and starts showing results within 6 hours. Ortho claims to prevent weed growth up to 1 year of application, which is a lot compared to competitors. This is because it works by destroying the roots of the weeds.

Ortho Clear Vegetation Killer eases the process if you have experimented with many products. It consists of Glyphosate and Imazapyr that work together to tackle all kinds of weeds. The product gets rainproof in an hour, which is very quick compared to others on the list.

There are three convenient methods of application- ready-to-use wand concentrates or a ready-to-use sprinkler cap. You can use it to kill the most annoying weeds on your flower beds, sidewalks, fences, or patios. It comes in a pre-mixed formula, which is excellent if you are a beginner to the DIY.


  • Affordable
  • It is non-selective, so it works on a wide variety of weeds.
  • Works on flower beds and also vegetable or fruit gardens without damaging edibles
  • Inhibits the growth of weeds for about a year after use


  • Best results when used on dry soil

Related: Best Powdery Mildew Fungicide

3. #3 Pick: Spectracide Grass and Weed Killer

Spectracide Weed & Grass Killer (Ready-to-Use) (HG-96428) (32 fl oz) (Pack of 2)
  • Visible results as fast as 3 hours
  • Kills the root
  • Rainfast in 15 minutes
  • Use around trees and shrubs, in flower beds and on patios and walkways

4. Compare-N-Save Concentrate Grass and Weed Killer

Compare-N-Save 75324 Herbicide, 1-gallon, white
  • Rainproof in 2 hours
  • Visible results in as little as 2 to 4 days
  • Contains 41-percent glyphosate
  • Covers over 25,000 square feet
  • Makes up to 85 gal. of ready-to-use spray. Note: Packaging may vary

The Compare-N-Save Weedkiller is a robust concentrated grass and weed killer that is composed of 41% glyphosate. 

It works on all annual and perennial weeds and most other unwanted plants. Apply the product by mixing it with water and spraying directly on to actively growing weeds.

The Compare-N-Save is a non-selective herbicide, so make sure it doesn’t reach the leaves, stems, or roots of any plants you don’t want to kill.

If you need season-long residual weed control, consider using a product like RM 43. The Compare-N-Save is cost-effective as it can be used on large areas of 25,000 square and more. The Compare-N-Save can be used around landscaping, passageways, and driveways, fences, and around buildings.

You may also use this product for restoring your lawn or renovation projects as well as for landscaping or preparing your plot. It is safe to plant new seeds after this product has been applied as it only kills actively growing weeds.

The magic lies in the 41% concentration glyphosate that works on the entire weed plant. You will need to make a mix of 1.5 oz, per 33 oz. of water and a little more for stubborn weeds. You will need to be careful not to let it reach the flowers, though.


  • Targets the roots of the plant
  • The high concentration which means you need less of the product to do the job
  • Can work on lawns of large areas


  • Some customers found the instructions on the product to be unclear.
  • Takes slightly longer to see results

Related: Fire Ant Killer

5. Scotts Halts Crabgrass & Grassy Weed Preventer

Compare-N-Save 75324 Herbicide, 1-gallon, white
  • Rainproof in 2 hours
  • Visible results in as little as 2 to 4 days
  • Contains 41-percent glyphosate
  • Covers over 25,000 square feet
  • Makes up to 85 gal. of ready-to-use spray. Note: Packaging may vary

The Scotts Halt is a weed preventer that needs to be used before the infestation of weeds. It is also one of the products featuring advanced weed grip technology. 

The Scotts Halt Weed Preventer does not affect the rest of the flowers, which is a bonus. As the Halt Weed Preventer is not affected by the cold, it can be used anytime during the year.

It works on adult weeds with a single application; unlike some formulas, it also kills juvenile and hidden weeds that are often missed.  This way, instead of the short-term results that comparable products offer, you get fast and long-lasting results on a budget.

Another factor that customers liked is that it can treat wide areas of more than 5,000 square feet. Scotts Weed Preventer also performs well in different weather conditions like rain, snow, and hot summer without hampering performance.

The Scott Halt uses an active ingredient Pendimethalin, making this is a selective herbicide. It will prevent the germination of seeds, so you will have to wait four months before planting flowers.


  • Suits different weather conditions
  • Can work on tough weeds
  • Safe to use around children and pets
  • Affordable


  • This product can stain your hand and clothes, so you would need to take precautions

6. Preen 2464083 Garden Weed Preventer

Preen 2464083 Garden Weed Preventer, 31.3 lb. Covers 5,000 sq. ft
  • Stop weeds before they start for up to 3 months guaranteed
  • Safe for use around over 200 established flowers, vegetables, trees and shrubs
  • Can be sold as a refill for flip-top applicator bottle
  • Apply anytime in spring, summer or fall
  • Not for use on lawns

While the Preen Weed prevention does not kill the weeds present in your flowerbed, it will prevent new weeds from growing and taking over your garden. For the best results, you will have to remove weeds from your flower bed. 

This product works on 27 types of flower weeds while not affecting the growth of 200 common flowers like roses, trees, vegetables, and shrubs. Customers have found that it works on any plant as long as it has grown to 2 to 3 inches tall.

The optimal time for applying the first round would be around spring. It is easy to apply and involves sprinkling the product on the soil or mulch. Generally, 1 ounce of Preen works per 10sq. Feet of soil. Water activates Preen, and you can use a hose or a sprinkler to do so.

It can affect the growth of the flowers, so you need to be careful while using it. Many customers place a barrier like cardboard around their flowers while applying the Preen formula. However, the spray is safe and can be used on flowering plants that have germinated.

Another feature we appreciate is that it does not get washed away in the rain and stay on the soil’s surface for long. This means that you do not have to reapply from often. Preen recommends that reapplication can be done every 9-12 weeks.

As it works like a weed preventer, it eliminates the need to get hands dirty and pull out weeds. Preen comes with a power spreader cap, which allows you to measure precisely.


  • Works on a wide variety of weeds
  • Can be used in all season
  • An applicator scoop is included.
  • Easy application


  • Needs to be applied when the soil is dry as it can cause discoloration of leaf damage otherwise
  • Reapplication during mid-season is important to maximize weed prevention

7. Roundup Weed and Grass Killer Concentrate Plus

Preen 2464083 Garden Weed Preventer, 31.3 lb. Covers 5,000 sq. ft
  • Stop weeds before they start for up to 3 months guaranteed
  • Safe for use around over 200 established flowers, vegetables, trees and shrubs
  • Can be sold as a refill for flip-top applicator bottle
  • Apply anytime in spring, summer or fall
  • Not for use on lawns

Roundup works to kills pre-existing weeds and prevents new ones from sprouting for up to four months. The weeds begin to wilt in 2-4 days and will be eradicated within two weeks. 

It is easy to apply and requires you to mix the concentrate with a given (on the label).

With a 50.2 % concentration of glyphosate, it can work on weeds’ toughest like vines, poison ivy, and poison oak. It comes in a pre-mixed formula, which will save you time and a separate sprayer cost.

Round up beings its action after just 3 hours of spraying. It takes only 30 minutes to be rainproof, which is a bonus. It also works as a pre-emergent weed killer and tackles both timelines of weed!

This product will not damage your flowers; however, be sure not to overspray it as you can risk slowing their growth. This product is a little heavy-duty but works well if you want to spend a little more for extra features.


  • Works as a Pre-and post-emergent herbicide
  • Offers up to four months of protection against new weeds
  • Can get rainproof within just 10 minutes
  • Affects the roots of the weed maximizing efficiency


  • Has a potent concentration, so you must be careful not to reapply around edible plants and trees.
  • Since it comes pre-mixed, it will not last as long as the other weed killers on this list

8. Natural Weed Killer Made with Ocean Water and Vinegar

Doctor Kirchner Natural Weed & Grass Killer (2.5 Gallon) No Hormone Disrupting Chemicals
  • A natural weed killer Made from ocean salt water, commercial strength food grade vinegar and soap.
  • Our non selective ready to spray Natural Weed & Grass Killer is not normally used on the lawn.
  • No Mixing, No Glyphosate and No Hormone Disrupting Chemicals

This Natural Weed Killer does not use chemical ingredients to deal with weeds. It uses natural ingredients such as commercial-grade vinegar, saltwater, and soap. This makes the Natural Weed Killer safe to use around pets and kids. 

The product is non-selective but will not damage your flowers or leaves. It is easy to use and comes with a spray bottle. The Natural Weed Killer starts working within 12 hours of spraying and eradicates the weeds 24 hours.

This product is great for organic gardeners out there. Another plus point is that its non-toxic formula will not contaminate your groundwater or soil. The company also claims that it is sustainable, which is a huge differentiator among other competing products.

Despite not having any chemicals, the product has a long shelf life and claims to last for 4 years.


  • Is safe for use around kids and pets
  • Is made of sustainable materials and is environmental-friendly
  • Provides highly effective and fast results
  • Easy to apply


  • The smell may be strong so some people
  • Priced higher than competitors

Check Post: Roach Killers

Guide to Buying a Weed Killer for Flower Beds

To help you decide which weed killer would work best for flower beds, here are some factors to think about.

1. Ingredients 

To be able to choose the right product, it’s essential also to find out the ingredient that is used. Below is the list of the most popular ingredients found in weed killers:

  • Glyphosate: An agrochemical, this is the most common ingredient used in mass-manufactured products.
  • Boric acid, Borax, and Borates: Easily available, these chemicals are often used for DIY.
  • Corn Gluten Meal: This is not very heavy duty and works for common, less-aggressive weeds.
  • Clopyralid: This is most commonly used to deal with broad-leaved weeds.
  • Diuron: A heavy-duty herbicide, this requires careful handling.
  • Natural: In recent times, we can find gentler and environmental methods like vinegar and soap being used

2. Methods of chemical treatment:

There are two primary methods of dealing with weeds such as:

Pre-emergent Weed killer:

  • There are many weed killers out there, and some are designed for killing the problematic weeds. But we recommend taking care of weeds before they’ve popped up. For that, you’ll need a pre-emergent weed killer, which is a protective barrier to prevent weeds from sprouting.
  • It stops the seeds of the weed from germinating, and if they have sprouted, it will stop them from taking root. Such products are best used on the edges of paths, fences, and other hard surfaces.

Post-emergent Weed Killer:  

  • Post-emergent weed killers work after the weeds have germinated and broken the ground. The advantage is that you wouldn’t have to hand pluck the weeds from the ground.
  • Now be very careful with choosing a selective or non-selective weed killer. A selective weed killer will not damage any other plant/flower beside the weeds, while a non-selective will damage anything it comes in contact with. Choose a non-selective weed killer only if your flower bed is rampant with weeds.


Weeds can ruin your hard work of growing and maintenance a flower bed. But with so many options out there, it can be challenging to choose the best weed killer that suits your requirements.

That is why this in-depth review has been made after a lot of research and testing a wide range of products so that you can find something that will work.


  1. Evaluation of weed control efficacy and crop safety of the new – NCBI
  2. Weed control – Wikipedia
  3. Trends in glyphosate herbicide use in the United States and – NCBI
  4. Roundup (herbicide) – Wikipedia

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